Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray

@article{Li2002EstablishmentOA,
  title={Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray},
  author={Yan Li and Zhao-you Tang and Sheng-long Ye and Binbin Liu and Yin-kun Liu and Jie Chen and Qiong Xue},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2002},
  volume={129},
  pages={43-51}
}
Abstract Purpose. To establish a hepatocellular carcinoma (HCC) cell line from lung metastatic lesions of human HCC in nude mice so as to provide a suitable model for the study of lung-metastasis-related molecular mechanisms. Methods. HCC clone cells MHCC97-H were inoculated into BALB/c nude mice, and the pulmonary metastatic lesions were harvested and re-implanted into nude mice for the second round of in vivo selection. The same procedure was repeated twice. A new cell line from the third… CONTINUE READING
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