Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells

@article{Li2017EstablishmentOR,
  title={Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells},
  author={M. Li and Huashan Zhao and G. Ananiev and Michael T Musser and Kathryn Ness and Dianne L Maglaque and K. Saha and A. Bhattacharyya and X. Zhao},
  journal={STEM CELLS},
  year={2017},
  volume={35}
}
  • M. Li, Huashan Zhao, +6 authors X. Zhao
  • Published 2017
  • Biology, Medicine
  • STEM CELLS
  • Human patient‐derived induced pluripotent stem cells (hiPSCs) provide unique opportunities for disease modeling and drug development. However, adapting hiPSCs or their differentiated progenies to high throughput assays for phenotyping or drug screening has been challenging. Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and a major genetic cause of autism. FXS is caused by mutational trinucleotide expansion in the FMR1 gene leading to hypermethylation and… CONTINUE READING
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