Establishment of Mouse Monoclonal Antibody LpMab-13 Against Human Podoplanin.

@article{Ogasawara2016EstablishmentOM,
  title={Establishment of Mouse Monoclonal Antibody LpMab-13 Against Human Podoplanin.},
  author={Satoshi Ogasawara and Mika Kato Kaneko and Ryusuke Honma and Hiroharu Oki and Yuki Fujii and Michiaki Takagi and Hiroyoshi Wako-shi Suzuki and Yukinari Kato},
  journal={Monoclonal antibodies in immunodiagnosis and immunotherapy},
  year={2016},
  volume={35 5},
  pages={
          254-258
        }
}
Podoplanin (PDPN)/Aggrus is a type-I transmembrane sialoglycoprotein, which possesses a platelet aggregation-stimulating (PLAG) domain. The O-glycosylation on Thr52 of human PDPN (hPDPN) is critical for the interaction of hPDPN with C-type lectin-like receptor-2 (CLEC-2), resulting in platelet aggregation. Many anti-hPDPN monoclonal antibodies (MAbs) against PLAG domains and non-PLAG domains have been established; however, mouse anti-PLAG2/3 MAb, the epitope of which is consistent with rat anti… CONTINUE READING

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