Establishment of H2O2-induced premature senescence in human fibroblasts concomitant with increased cellular production of H2O2.

@article{Zdanov2006EstablishmentOH,
  title={Establishment of H2O2-induced premature senescence in human fibroblasts concomitant with increased cellular production of H2O2.},
  author={St{\'e}phanie Zdanov and Jos{\'e} Remacle and Olivier Toussaint},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1067},
  pages={210-6}
}
Premature senescence of human fibroblasts is established after exposure to an acute sublethal concentration of H(2)O(2). Overexpression of transforming growth factor-beta1 (TGF-beta1) was shown to be responsible for the appearance of the biomarkers of senescence in these conditions. Other studies have shown that incubation of human fibroblasts with TGF-beta1 leads to overexpression of H(2)O(2). In this work, we show an increased production of H(2)O(2) by human fibroblasts as premature… CONTINUE READING

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