Establishment of Gastrointestinal Epithelial Organoids.

@article{Mahe2013EstablishmentOG,
  title={Establishment of Gastrointestinal Epithelial Organoids.},
  author={Maxime M Mahe and Eitaro Aihara and Michael A. Schumacher and Yana Zavros and Marshall H Montrose and Michael A. Helmrath and Toshiro Sato and Noah F Shroyer},
  journal={Current protocols in mouse biology},
  year={2013},
  volume={3 4},
  pages={217-40}
}
The intestinal epithelium constitutes a system of constant and rapid renewal triggered by proliferation of intestinal stem cells (ISCs), and is an ideal system for studying cell proliferation, migration, and differentiation. Primary cell cultures have proven to be promising for unraveling the mechanisms involved in epithelium homeostasis. In 2009, Sato et al. established a long-term primary culture to generate epithelial organoids (enteroids) with crypt- and villus-like epithelial domains… CONTINUE READING

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