Establishment in severe combined immunodeficiency mice of subrenal capsule xenografts and transplantable tumor lines from a variety of primary human lung cancers: potential models for studying tumor progression-related changes.

@article{Cutz2006EstablishmentIS,
  title={Establishment in severe combined immunodeficiency mice of subrenal capsule xenografts and transplantable tumor lines from a variety of primary human lung cancers: potential models for studying tumor progression-related changes.},
  author={Jean-Claude Cutz and Jun Guan and Jane Bayani and Maisa Yoshimoto and Hui Xue and Margaret Sutcliffe and J. S. C. English and Julia Flint and Jean Leriche and John Yee and Jeremy A. Squire and Peter W. Gout and Stephen Lam and Yuzhuo Wang},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 13},
  pages={
          4043-54
        }
}
PURPOSE Lung cancer is a biologically diverse disease and relevant models reflecting its diversity would facilitate the improvement of existing therapies. With a view to establishing such models, we developed and evaluated xenografts of a variety of human lung cancers. EXPERIMENTAL DESIGN Using nonobese diabetic/severe combined immunodeficiency mice, subrenal capsule xenografts were generated from primary lung cancer tissue, including moderately and poorly differentiated squamous cell… CONTINUE READING

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