Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome.

@article{Crdenas2002EstablishmentAC,
  title={Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome.},
  author={Ana Mar{\'i}a C{\'a}rdenas and David D. Allen and Christian Arriagada and Alexis Olivares and Lori B. Bennett and Ra{\'u}l Caviedes and A Dagnino-Subiabre and Isabel E Mendoza and Juan Segura-Aguilar and Stanley I. Rapoport and Pablo A Caviedes},
  journal={Journal of neuroscience research},
  year={2002},
  volume={68 1},
  pages={46-58}
}
We report the establishment of continuously growing cell lines from spinal cords of normal and trisomy 16 fetal mice. We show that both cell lines, named M4b (derived from a normal animal) and MTh (trisomic) possess neurological markers by immunohistochemistry (neuron specific enolase, synaptophysin, microtubule associated protein-2 [MAP-2], and choline acetyltransferase) and lack glial traits (glial fibrillary acidic protein and S100). MTh cells were shown to overexpress mRNA of Cu/Zn… CONTINUE READING

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