Establishment and characterization of human gastric and colonic xenograft lines resistant to CPT-11 (a new derivative of camptothecin).

@article{Nagai1995EstablishmentAC,
  title={Establishment and characterization of human gastric and colonic xenograft lines resistant to CPT-11 (a new derivative of camptothecin).},
  author={Sonoko Nagai and Masaji Yamauchi and Toshiwo Andoh and Masafumi Nishizawa and Tetsuya Satta and Yasuhiro Kodera and Keiko Kondou and Shin-ichi Akiyama and Katsuki Ito and Hideyasu Takagi},
  journal={Journal of surgical oncology},
  year={1995},
  volume={59 2},
  pages={116-24}
}
CPT-11-resistant human gastric and colonic xenograft lines were established by direct intratumoral injection of CPT-11 into subcutaneous SC-1-NU and CC-2-NU tumors in nude mice once a week for 10 months. The resistance of these xenograft lines to CPT-11 was confirmed by growth inhibition rate, to be 36.3% and 45.4%, respectively, compared to each parent cell line. DNA topoisomerase I activity of the nuclear extracts of SC-1-NU/CPT-11 and CC-2-NU/CPT-11, as assayed by relaxation of supercoiled… CONTINUE READING