Establishment and characterization of hamster cell lines transformed by restriction endonuclease fragments of adenovirus 5.

@article{Rowe1984EstablishmentAC,
  title={Establishment and characterization of hamster cell lines transformed by restriction endonuclease fragments of adenovirus 5.},
  author={David T. Rowe and Philip E. Branton and Sinclair Yee and Silvia Bacchetti and Frank L. Graham},
  journal={Journal of virology},
  year={1984},
  volume={49 1},
  pages={162-70}
}
We have established a library of hamster cells transformed by adenovirus 5 DNA fragments comprising all (XhoI-C, 0 to 16 map units) or only a part (HindIII-G, 0 to 7.8 map units) of early region 1 (E1: 0 to 11.2 map units). These lines have been analyzed in terms of content of viral DNA, expression of E1 antigens, and capacity to induce tumors in hamsters. All cells tested were found to express up to eight proteins encoded within E1A (0 to 4.5 map units) with apparent molecular weights between… CONTINUE READING
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The 2.2 kb mRNA of the E1B region of human adenovirus type 5 and 12 directs the synthesis of two major antigens from different AUG triplets. Cell 27:121-131

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