Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines: focus on the contribution of the AP-1 transcription factor.

@article{Boeckx2015EstablishmentAC,
  title={Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines: focus on the contribution of the AP-1 transcription factor.},
  author={Carolien Boeckx and Lina Blockx and Ken Op de Beeck and Ridha Limame and Guy Van Camp and Marc Peeters and Jan Baptist Vermorken and Pol Specenier and An Wouters and Marc F. D. Baay and Filip Lardon},
  journal={American journal of cancer research},
  year={2015},
  volume={5 6},
  pages={1921-38}
}
BACKGROUND After an initial response to EGFR targeted therapy, secondary resistance almost invariably ensues, thereby limiting the clinical benefit of the drug. Hence, it has been recognized that the successful implementation of targeted therapy in the treatment of HNSCC cancer is very much dependent on predictive biomarkers for patient selection. METHODS We generated an in vitro model of acquired cetuximab resistance by chronically exposing three HNSCC cell lines to increasing cetuximab… CONTINUE READING