Establishment and characterization of an immature human megakaryoblastic cell line, MEG-A2.

@article{Abe1995EstablishmentAC,
  title={Establishment and characterization of an immature human megakaryoblastic cell line, MEG-A2.},
  author={A Abe and Nobuhiko Emi and Harumi Kato and Koichi Adachi and Takashi Murate and Shinsuke Saga and Michinori Ogura and Takashi Kojima and Mitsune Tanimoto and Nobumasa Morishita},
  journal={Leukemia},
  year={1995},
  volume={9 2},
  pages={341-9}
}
We have established a novel human megakaryoblastic cell line, designated as MEG-A2, from a patient with megakaryoblastic crisis of Philadelphia (Ph) chromosome positive chronic myelogenous leukemia. MEG-A2 cells showed positive phenotypes for periodic acid Schiff and alpha-naphthylbutyrate esterase reactions, but were negative for myeloperoxidase and naphthol ASD chloroacetate esterase reactions. Flow cytometric analyses of cell surface markers revealed that MEG-A2 cells had a low level of GP… CONTINUE READING