Establishment and characterization of a mouse FM3A cell mutant resistant to topoisomerase II-inhibitor NC-190


We established an NC-190-resistant cell line, FM/NC-R, from the murine mammary carcinoma cell line FM3A and examined some of its characteristics. FM/NC-R cells were prepared by mutagen treatment followed by exposure to NC-190 in the culture medium. FM/NC-R cells were 76.5 times more resistant against NC-190 than FM3A cells as measured by their growth in… (More)
DOI: 10.1007/s00280-002-0508-5


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