Establishment and characterization of a human prostatic carcinoma cell line (PC-3).

@article{Kaighn1979EstablishmentAC,
  title={Establishment and characterization of a human prostatic carcinoma cell line (PC-3).},
  author={M. Edward Kaighn and Karthik S. Narayan and Yasushi Ohnuki and John F. Lechner and Lee Jones},
  journal={Investigative urology},
  year={1979},
  volume={17 1},
  pages={16-23}
}
The establishment, characterization, and tumorigenicity of a new epithelial cell line (PC-3) from a human prostatic adenocarcinoma metastatic to bone is reported. The cultured cells show anchorage-independent growth in both monolayers and in soft agar suspension and produce subcutaneous tumors in nude mice. Culture of the transplanted tumor yielded a human cell line with characteristics identical to those used initially to produce the tumor. PC-3 has a greatly reduced dependence upon serum for… CONTINUE READING
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