Establishment and characterization of a chordoma cell line from the tissue of a patient with dedifferentiated-type chordoma.

@article{Kim2016EstablishmentAC,
  title={Establishment and characterization of a chordoma cell line from the tissue of a patient with dedifferentiated-type chordoma.},
  author={Jeong-Yub Kim and Jongsun Lee and J Koh and M Park and U K Chang},
  journal={Journal of neurosurgery. Spine},
  year={2016},
  volume={25 5},
  pages={626-635}
}
OBJECTIVE Chordoma is a rare bone tumor of the axial skeleton believed to originate from the remnants of the embryonic notochord. The available tumor cells are characteristically physaliferous and express brachyury, a transcription factor critical for mesoderm specification. Although chordomas are histologically not malignant, treatments remain challenging because they are resistant to radiation therapy and because wide resection is impossible in most cases. Therefore, a better understanding of… CONTINUE READING
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