Establishment and Characterization of a High Metastatic Potential in the Peritoneum for Human Gastric Cancer by Orthotopic Tumor Cell Implantation

@article{Bai2006EstablishmentAC,
  title={Establishment and Characterization of a High Metastatic Potential in the Peritoneum for Human Gastric Cancer by Orthotopic Tumor Cell Implantation},
  author={Feihu Bai and Xinning Guo and Li Yang and Jun Wang and Yongquan Shi and Faming Zhang and Huihong Zhai and Yuanyuan Lu and Huahong Xie and Kaichun Wu and Dai-ming Fan},
  journal={Digestive Diseases and Sciences},
  year={2006},
  volume={52},
  pages={1571-1578}
}
The aim of this study was to establish an orthotopic implantation model with high metastasis of gastric cancer to the peritoneum which is more faithful to clinical metastasis. A human gastric carcinoma cell line, GC9811, was injected as a single-cell suspension into the stomach of nude mice. The cells from some peritoneum metastatic foci were expanded in vitro and subsequently implanted to the stomach wall of nude mice. By repeating the in vivo stepwise selection method for four rounds and… CONTINUE READING
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