Establishing the phenotype in novel acute and chronic murine models of allergic asthma.

@article{FernandezRodriguez2008EstablishingTP,
  title={Establishing the phenotype in novel acute and chronic murine models of allergic asthma.},
  author={Sofia Fernandez-Rodriguez and William R. Ford and Kenneth J. Broadley and Emma J. Kidd},
  journal={International immunopharmacology},
  year={2008},
  volume={8 5},
  pages={756-63}
}
Allergic asthma is a chronic disease of the airways, with superimposed acute inflammatory episodes which correspond to exacerbations of asthma. Two novel models of allergic asthma have been developed in mice receiving the same allergen sensitisation, but with acute or chronic allergen exposures, the latter to mimic the human situation more closely. Ovalbumin-sensitised mice were challenged by ovalbumin inhalation twice on the same day for the acute model, and 18 times over a period of 6 weeks… CONTINUE READING