Establishing equivalence of two treatments and sample size requirements in matched-pairs design.

@article{Nam1997EstablishingEO,
  title={Establishing equivalence of two treatments and sample size requirements in matched-pairs design.},
  author={Jun-mo Nam},
  journal={Biometrics},
  year={1997},
  volume={53 4},
  pages={1422-30}
}
Statistical methods for testing the null hypothesis of a nonzero difference between two treatments and the sample size determination for matched-pairs studies are investigated. A Wald-type test proposed by Lu and Bean (1995, Statistics in Medicine 14, 1831-1839) is anticonservative, i.e., its false positive error rate is greater than specified. Score method and normal deviate based on a restricted maximum likelihood estimation are presented. These two test statistics are shown to be… CONTINUE READING

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