Establishing equivalence by showing that a specified percentage of the effect of the active control over placebo is maintained.

@article{Holmgren1999EstablishingEB,
  title={Establishing equivalence by showing that a specified percentage of the effect of the active control over placebo is maintained.},
  author={Eric Holmgren},
  journal={Journal of biopharmaceutical statistics},
  year={1999},
  volume={9 4},
  pages={651-9}
}
  • Eric Holmgren
  • Published 1999 in Journal of biopharmaceutical statistics
We propose a procedure for establishing equivalence that determines whether a specified percentage of the treatment effect of a known active agent over placebo is maintained. This procedure accounts for the error in the estimates from the historical studies of the known active agent and placebo as well as the error in the estimates from the equivalence study of the new test treatment versus the active control. After the procedure is presented, it is compared analytically to a procedure in which… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
14 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…