Establishing epigenetic domains via chromatin-bound histone modifiers.

  title={Establishing epigenetic domains via chromatin-bound histone modifiers.},
  author={Fabian Erdel and Katharina M{\"u}ller-Ott and Karsten Rippe},
  journal={Annals of the New York Academy of Sciences},
The eukaryotic nucleus harbors the DNA genome, which associates with histones and other chromosomal proteins into a complex referred to as chromatin. It provides an additional layer of so-called epigenetic information via histone modifications and DNA methylation on top of the DNA sequence that determines the cell's active gene expression program. The nucleus is devoid of internal organelles separated by membranes. Thus, free diffusive transport of proteins and RNA can occur throughout the… CONTINUE READING