Establishing cell polarity in development

  title={Establishing cell polarity in development},
  author={Andreas Wodarz},
  journal={Nature Cell Biology},
Polarity is a common feature of many different cell types, including the Caenorhabditis elegans zygote, the Drosophila oocyte and mammalian epithelial cells. The initial establishment of cell polarity depends on asymmetric cues that lead to reorganization of the cytoskeleton and polarized localization of several cortical proteins that act downstream of the polarization cues. The past year revealed that homologs of the C. elegans par (partitioning defective) genes are also essential for… CONTINUE READING

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