Establishing a stable, repeatable platform for measuring changes in sperm DNA methylation

  title={Establishing a stable, repeatable platform for measuring changes in sperm DNA methylation},
  author={Mohammad Abbasi and A. David Smith and Harish Swaminathan and Peer Sangngern and Amanda Douglas and Alan Horsager and Douglas T. Carrell and Philip J. Uren},
  booktitle={Clinical Epigenetics},
Several independent research groups have shown that alterations in human sperm methylation profiles correlate with decreased fecundity and an increased risk of poor embryo development. Moving these initial findings from the lab into a clinical setting where they can be used to measure male infertility though requires a platform that is stable and robust against batch effects that can occur between sample runs. Operating parameters must be established, performance characteristics determined, and… CONTINUE READING
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