Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome.

@article{Plett2012EstablishingAM,
  title={Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome.},
  author={Paul Artur Plett and Carol H Sampson and Hui Lin Chua and Mandar S. Joshi and Catherine Booth and A. L. Gough and Cynthia S. Johnson and Barry P. Katz and Ann M Farese and Jeffrey Parker and Thomas J Macvittie and Christie M. Orschell},
  journal={Health physics},
  year={2012},
  volume={103 4},
  pages={343-55}
}
The authors have developed a murine model of the Hematopoietic Syndrome of the Acute Radiation Syndrome (H-ARS) for efficacy testing of medical countermeasures (MCM) against radiation according to the FDA Animal Rule. Ten- to 12-wk-old male and female C57BL/6 mice were exposed to the LD50/30-LD70/30 dose of total body irradiation (TBI, (137)Cs, 0.62-0.67 Gy min(-1)) in the morning hours when mice were determined to be most radiosensitive, and they were assessed for 30-d survival and mean… CONTINUE READING

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