Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds.

Abstract

Despite their usefulness as fluorophores and synthetic precursors, efficient and reliable routes to coumarin-8-carbaldehydes are lacking. We describe here a high-yielding continuous flow synthesis that requires no manual intermediate purification or work-up, giving access to multigram quantities of the aldehyde product.

DOI: 10.1002/chem.201201039

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Cite this paper

@article{Zk2012EstablishingAF, title={Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds.}, author={Jaroslav Z{\'a}k and David Ron and Elena Riva and Heather P Harding and Benedict C.S. Cross and Ian R. Baxendale}, journal={Chemistry}, year={2012}, volume={18 32}, pages={9901-10} }