Essentials of insulin pharmacokinetics.

@article{Turnheim1988EssentialsOI,
  title={Essentials of insulin pharmacokinetics.},
  author={Klaus Turnheim and Werner Waldh{\"a}usl},
  journal={Wiener klinische Wochenschrift},
  year={1988},
  volume={100 3},
  pages={65-72}
}
Pharmacokinetic methods are a powerful tool for the investigation of the insulin system in health and disease; the underlying formalisms are simple and straight-foreward. Following intravenous injection the plasma concentration of insulin declines with at least two exponentials, the rapidly disappearing component (half-time 2.4 min) represents elimination from the intravascular space, whereas the most slowly disappearing component (half-time 50-130 min) reflects elimination from the… CONTINUE READING

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