• DOI:10.1080/15287390903337100
Corpus ID: 1621978

Essentiality and Toxicity in Copper Health Risk Assessment: Overview, Update and Regulatory Considerations

@article{Stern2010EssentialityAT,
  title={Essentiality and Toxicity in Copper Health Risk Assessment: Overview, Update and Regulatory Considerations},
  author={B. Stern},
  journal={Journal of Toxicology and Environmental Health, Part A},
  year={2010},
  volume={73},
  pages={114 - 127}
}

B. Stern

Published 2010

Medicine, Biology

Journal of Toxicology and Environmental Health, Part A

Copper (Cu), an essential element required as a cofactor and/or structural component of numerous metalloenzymes, is uniquely positioned as a case study for issues associated with the essential metals health risk assessment, because of its extensive database. Essential elements pose distinct challenges when establishing regulatory guidelines because too little as well as too much intake can produce adverse health consequences and the dose-response curve is roughly U-shaped. Thus, conventional… CONTINUE READING

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