Essentiality, not expressiveness, drives gene-strand bias in bacteria

  title={Essentiality, not expressiveness, drives gene-strand bias in bacteria},
  author={Eduardo P. C. Rocha and Antoine Danchin},
  journal={Nature Genetics},
Preferential positioning of bacterial genes in the leading strand was thought to result from selection to avoid high head-on collision rates between DNA and RNA polymerases. Here we show, however, that in Bacillus subtilis and Escherichia coli, essentiality (the transcript product), not expressiveness (the collision rate), selectively drives the biased gene distribution. 
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NATURE GENETICS Table 1 Number of genes and statistical tests Number of genes Percentage of genes lead Statistical tests Genome E NE EH ENH NEH NENH E > NE NEH > NENH ENH > NEH B. subtilis

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