Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit.

@article{Tan2005EssentialTA,
  title={Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit.},
  author={Agnes Lay-Choo Tan and Padmashree C. G. Rida and Uttam Surana},
  journal={The Biochemical journal},
  year={2005},
  volume={386 Pt 1},
  pages={1-13}
}
Replicated genetic material must be partitioned equally between daughter cells during cell division. The precision with which this is accomplished depends critically on the proper functioning of the mitotic spindle. The assembly, orientation and attachment of the spindle to the kinetochores are therefore constantly monitored by a surveillance mechanism termed the SCP (spindle checkpoint). In the event of malfunction, the SCP not only prevents chromosome segregation, but also inhibits subsequent… CONTINUE READING

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The anaphase-promoting complex: proteolysis in mitosis and beyond.

Molecular cell • 2002
View 10 Excerpts
Highly Influenced

Bifurcation of the mitotic checkpoint pathway in budding yeast.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 10 Excerpts
Highly Influenced

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex.

Molecular biology of the cell • 2002
View 3 Excerpts
Highly Influenced

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