Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration.

@article{Ishida2007EssentialRO,
  title={Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration.},
  author={Yuko Ishida and Akihiko Kimura and Toshikazu Kondo and Takahito Hayashi and Masaya Ueno and Nobuyuki Takakura and Kouji Matsushima and Naofumi Mukaida},
  journal={The American journal of pathology},
  year={2007},
  volume={170 3},
  pages={843-54}
}
We investigated the pathogenic roles of CC chemokine ligand (CCL)3 and its receptors, CC chemokine receptor (CCR)1 and CCR5, in bleomycin (BLM)-induced pulmonary fibrosis (PF). An intratracheal injection of BLM into wild-type (WT) mice caused a massive infiltration of granulocytes and macrophages, followed by the development of diffuse PF with fibrocyte accumulation. Intrapulmonary CCL3 expression was enhanced rapidly and remained at elevated levels until PF developed. Moreover, CCL3 protein… CONTINUE READING

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