Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death.

@article{Shen2004EssentialRO,
  title={Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death.},
  author={Han-ming Shen and Yong Lin and Swati Choksi and Jamie Hong Tran and Tian Jin and Lufen Chang and Michael Karin and Jianke Zhang and Zheng-gang Liu},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 13},
  pages={5914-22}
}
Oxidative stress and reactive oxygen species (ROS) can elicit and modulate various physiological and pathological processes, including cell death. However, the mechanisms controlling ROS-induced cell death are largely unknown. Data from this study suggest that receptor-interacting protein (RIP) and tumor necrosis factor receptor (TNFR)-associated factor 2 (TRAF2), two key effector molecules of TNF signaling, are essential for ROS-induced cell death. We found that RIP(-/-) or TRAF2(-/-) mouse… CONTINUE READING

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