Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3‐phosphate dynamics

  title={Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3‐phosphate dynamics},
  author={K. Hazeki and K. Nigorikawa and Y. Takaba and T. Segawa and Akiko Nukuda and Ayaka Masuda and Y. Ishikawa and Koji Kubota and Shunsuke Takasuga and O. Hazeki},
  journal={FEBS Letters},
  • K. Hazeki, K. Nigorikawa, +7 authors O. Hazeki
  • Published 2012
  • Biology, Medicine
  • FEBS Letters
  • PtdIns(3)P (phosphatidylinositol 3‐phosphate) is a signaling molecule important for phagosome maturation. The major role of Vps34 in production of phagosomal PtdIns(3)P has been indicated. However, the fate of the newly generated PtdIns(3)P has not been well described. Here we show that elimination of PtdIns(3)P from phagosomal membrane was significantly delayed in RAW264.7 macrophages lacking PTEN or PIKfyve. In the PTEN‐deficient cells treated with a PIKfyve inhibitor, degradation of PtdIns(3… CONTINUE READING
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