Essential roles for the Dhr78 orphan nuclear receptor during molting of the Drosophila tracheal system.

@article{Astle2003EssentialRF,
  title={Essential roles for the Dhr78 orphan nuclear receptor during molting of the Drosophila tracheal system.},
  author={John M. Astle and Tatiana A. Kozlova and Carl S Thummel},
  journal={Insect biochemistry and molecular biology},
  year={2003},
  volume={33 12},
  pages={
          1201-9
        }
}
The Drosophila Dhr78 orphan nuclear receptor has been proposed to play a role in molting of the tracheal cuticle and regulate gene expression during the third larval instar, possibly in response to a novel systemic hormonal signal. Here, we show that there are no essential maternal functions for Dhr78 during development, and that mutants missing both maternal and zygotic Dhr78 function die primarily during second and third instar larval development. We show that defects in the tracheal system… CONTINUE READING
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