Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice.

@article{Zhang2011EssentialRO,
  title={Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice.},
  author={Yi Zhang and Hui Li and Yi Li and Xiuli Sun and Mengyang Zhu and Gregory A. Hanley and Gene D Lesage and Deling Yin},
  journal={Neuroscience letters},
  year={2011},
  volume={489 1},
  pages={43-7}
}
Opioids are powerful pain relievers, but also potent inducers of dependence and tolerance. Chronic morphine administration (via subcutaneous pellet) induces morphine dependence in the nucleus accumbens, an important dependence region in the brain, yet the cellular mechanisms are mostly unknown. Toll-like receptor 2 (TLR2) plays an essential function in controlling innate and inflammatory responses. Using a knockout mouse lacking TLR2, we assessed the contribution of TLR2 to microglia activation… CONTINUE READING

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