Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.

@article{Kurotaki2013EssentialRO,
  title={Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.},
  author={Daisuke Kurotaki and Naoki Osato and Akira Nishiyama and Michio Yamamoto and Tatsuma Ban and Hideaki Sato and Jun Nakabayashi and Marina Umehara and Noriko Miyake and Naomichi Matsumoto and Masatoshi Nakazawa and Keiko Ozato and Tomohiko Tamura},
  journal={Blood},
  year={2013},
  volume={121 10},
  pages={
          1839-49
        }
}
Monocytes regulate host defenses, inflammation, and tissue homeostasis. The transcription factor interferon regulatory factor-8 (IRF8) stimulates monocyte/macrophage differentiation, yet genome-wide understanding of the differentiation program initiated by IRF8 is lacking. By combining chromatin immunoprecipitation sequencing with gene expression profiling, we show that during IRF8-dependent monocyte differentiation, IRF8 binding occurs at both promoter-proximal and promotor-distal regions… Expand
Transcriptional and Epigenetic Regulation of Innate Immune Cell Development by the Transcription Factor, Interferon Regulatory Factor-8.
  • D. Kurotaki, T. Tamura
  • Biology, Medicine
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2016
TLDR
Recent advances in the understanding of transcriptional and epigenetic regulation involving IRF8 in the development of myeloid cells are discussed. Expand
A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages.
TLDR
Overall, these data show at the genome scale how the same TF can be linked to constitutive and inducible gene regulation via distinct combinations of alternative DNA-binding sites. Expand
Regulation of myelopoiesis by the transcription factor IRF8
TLDR
An overview of recent advances in the understanding of the role of IRF8 in myelopoiesis and related diseases is provided. Expand
IRF8-dependent molecular complexes control the Th9 transcriptional program
TLDR
It is shown that IRF8 forms a complex with IRF4, PU.1 and BATF to modulate the Th9 transcription program and expression of IL-4 and IL-9, thereby implicating IRf8 as a potential therapeutic target to affect Th9 responses in cancer therapy. Expand
Interferon regulatory factor 8 and the regulation of neutrophil, monocyte, and dendritic cell production
TLDR
This review discusses recent studies that have revealed molecular mechanisms underlying the regulation of myelopoiesis by IRF8, which cooperates with other transcription factors to control the initiation of gene expression programs that define the development of specific myeloid cell subsets. Expand
A RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes.
TLDR
It is demonstrated that high, low or null expression of IRF8 in hematopoietic progenitor cells promotes differentiation toward type 1 conventional DCs, Ly6C+ monocytes or neutrophils, respectively, via epigenetic regulation of distinct sets of enhancers in cooperation with other transcription factors. Expand
Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.
TLDR
The results illustrate the dynamic process by which key transcription factors regulate enhancer formation and, therefore, direct future gene expression to achieve mononuclear phagocyte development. Expand
The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.
TLDR
It is found that Irf8(-/-) mice are resistant to EAE, and mechanistic bases by which IRF8 contributes to the pathogenesis of MS are provided. Expand
Cooperation of PU.1 With IRF8 and NFATc1 Defines Chromatin Landscapes During RANKL‐Induced Osteoclastogenesis
  • Naohiro Izawa, D. Kurotaki, +12 authors Sakae Tanaka
  • Chemistry, Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2019
TLDR
The results suggest that PU.1 switches its transcription partner from IRF8 to NFATc1 and alters the binding regions during RANKL‐induced osteoclastogenesis, which is associated with changes in epigenetic profiles and the control of cell type–specific gene expression. Expand
Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages
TLDR
It is proposed that GR and KLFs functionally cooperate to curb inflammation by regulating multiple transcription factors, which propagate the initial hormonal signal, GR acts as a coordinating hub in anti-inflammatory responses. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 45 REFERENCES
Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development
TLDR
It is shown that IRF4 has activities similar to IRF8 in regulating myeloid cell development, and it is demonstrated that Irf8 -/- Irf4 -/- mice exhibit a more severe chronic myeloids leukemia (CML)-like disease than IrF8 -/+ mice, involving a disproportionate expansion of granulocytes at the expense of monocytes/macrophages. Expand
Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages.
TLDR
Data indicate that IRF-8 stimulates transcription of target genes through a novel cis element to specify macrophage differentiation. Expand
Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis
TLDR
Results identify IRF8 as a key regulator of early response pathways in myeloids cells, including phagosome maturation, antigen processing, and antigen presentation by myeloid cells. Expand
The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells.
TLDR
It is suggested that IRF8 and PU.1 can have both combined, and independent actions on different promoters in myeloid cells. Expand
Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages.
TLDR
The combinatorial assembly of tissue- and signal-specific transcription factors determines the activity of a distinct group of enhancers and it is suggested that this may represent a general paradigm in tissue-restricted and stimulus-responsive gene regulation. Expand
The Kruppel‐like factor KLF4 is a critical regulator of monocyte differentiation
TLDR
It is shown that KLF4/GKLF is expressed in a monocyte‐restricted and stage‐specific pattern during myelopoiesis and functions to promote monocyte differentiation. Expand
ICSBP/IRF-8: its regulatory roles in the development of myeloid cells.
  • T. Tamura, K. Ozato
  • Biology, Medicine
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2002
TLDR
The mechanism by which the loss of ICSBP leads to immunodeficiency and CML-like syndrome is illustrated and ICS BP's critical role in the development of myeloid cells is suggested. Expand
The IRF family transcription factors in immunity and oncogenesis.
TLDR
The role of several IRF family members in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers. Expand
MafB is an inducer of monocytic differentiation
TLDR
The results indicate that MafB induction is a specific and essential determinant of the monocytic program in hematopoietic cells. Expand
Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein.
TLDR
ICSBP−/− myeloid progenitor cells share several abnormal features with CML progenitors, suggesting that the distal parts of signaling pathways of these two disorders are overlapping. Expand
...
1
2
3
4
5
...