Essential role of tau phosphorylation in adult hippocampal neurogenesis.

  title={Essential role of tau phosphorylation in adult hippocampal neurogenesis.},
  author={Xiao-ping Hong and Cai-Xia Peng and Wei Wei and Q. I. Tian and Ying-Hua Liu and Xiu-Qing Yao and Yao Zhang and Fu-yuan Cao and Qun Wang and Jian-Zhi Wang},
  volume={20 12},
An increased hippocampal neurogenesis has been observed in Alzheimer disease (AD), the most common neurodegenerative disorder characterized with accumulation of β-amyloid (Aβ) and hyperphosphorylated tau (p-tau). Studies in transgenic mouse models suggest that the amyloidosis suppresses adult neurogenesis. Although emerging evidence links tau to neurodevelopment, the direct data regarding tau phosphorylation in adult neurogenesis is missing. Here, we found that the immature neurons, identified… CONTINUE READING


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