Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.

@article{Adams2000EssentialRO,
  title={Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.},
  author={Ralf H Adams and Almudena Porras and Gema Alonso and Margaret Jones and Kristina Vintersten and Simona Panelli and Amparo Valladares and Lidia Mart{\'i}nez P{\'e}rez and Rodika Klein and Angel R Nebreda},
  journal={Molecular cell},
  year={2000},
  volume={6 1},
  pages={109-16}
}
p38alpha MAP kinase is activated in response to many cellular stresses and also regulates the differentiation and/or survival of various cell types in vitro, including skeletal muscle cells and cardiomyocytes. Here we show that targeted inactivation of the mouse p38alpha gene results in embryonic lethality at midgestation correlating with a massive reduction of the myocardium and malformation of blood vessels in the head region. However, this defect appears to be secondary to insufficient… CONTINUE READING

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