Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1.

@article{Matsumoto2004EssentialRO,
  title={Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1.},
  author={Masahito Matsumoto and Masakazu Kogawa and Seiki Wada and Hiroshi Takayanagi and Masafumi Tsujimoto and Shigehiro Katayama and Koji Hisatake and Yasuhisa Nogi},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 44},
  pages={45969-79}
}
The receptor activator of NF-kappaB ligand (RANKL) induces various osteoclast-specific marker genes during osteoclast differentiation mediated by mitogen-activated protein (MAP) kinase cascades. However, the results of transcriptional programming of an osteoclast-specific cathepsin K gene are inconclusive. Here we report the regulatory mechanisms of RANKL-induced cathepsin K gene expression during osteoclastogenesis in a p38 MAP kinase-dependent manner. The reporter gene analysis with… CONTINUE READING
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