Essential role of p38 MAPK for activation of skeletal muscle glucose transport by lithium

  title={Essential role of p38 MAPK for activation of skeletal muscle glucose transport by lithium},
  author={Nicholas B. Harrell and M. K. Teachey and N. Gifford and E. Henriksen},
  journal={Archives Of Physiology And Biochemistry},
  pages={221 - 227}
  • Nicholas B. Harrell, M. K. Teachey, +1 author E. Henriksen
  • Published 2007
  • Biology, Medicine
  • Archives Of Physiology And Biochemistry
  • Abstract Lithium increases glucose transport and glycogen synthesis in insulin-sensitive cell lines and rat skeletal muscle, and has been used as a non-selective inhibitor of glycogen synthase kinase-3 (GSK-3). However, the molecular mechanisms underlying lithium action on glucose transport in mammalian skeletal muscle are unknown. Therefore, we examined the effects of lithium on glucose transport activity, glycogen synthesis, insulin signaling elements (insulin receptor (IR), Akt, and GSK-3… CONTINUE READING
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