Essential role of osteopontin in smoking-related interstitial lung diseases.

  title={Essential role of osteopontin in smoking-related interstitial lung diseases.},
  author={Antje Prasse and Mirjam Stahl and Guido Schulz and Gian Kayser and Lingqiao Wang and Kjetil Ask and Jasmin Yalcintepe and Andreas Kirschbaum and Elena Bargagli and Gernot Zissel and Martin Kolb and Joachim M{\"u}ller-Quernheim and Johannes Martin Weiss and Andreas C. Renkl},
  journal={The American journal of pathology},
  volume={174 5},
Smoking-related interstitial lung diseases are characterized by the accumulation of macrophages and Langerhans cells, and fibrotic remodeling, which are linked to osteopontin (OPN) expression. Therefore, OPN levels were investigated in bronchoalveolar lavage (BAL) cells in 11 patients with pulmonary Langerhans cell histiocytosis (PLCH), 15 patients with desquamative interstitial pneumonitis (DIP), 10 patients with idiopathic pulmonary fibrosis, 5 patients with sarcoidosis, 13 otherwise healthy… CONTINUE READING