Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate.

@article{Fromigu2010EssentialRO,
  title={Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate.},
  author={Olivia Fromigu{\'e} and Eric Ha{\"y} and Alain Barbara and Pierre Jacques Marie},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 33},
  pages={25251-8}
}
The antiosteoporotic treatment strontium ranelate (SrRan) was shown to increase bone mass and strength by dissociating bone resorption and bone formation. To identify the molecular mechanisms of action of SrRan on osteoblasts, we investigated its effects on calcineurin-NFAT (nuclear factor of activated T cells) signaling, an important calcium sensitive pathway controlling bone formation. Using murine MC3T3-E1 and primary murine osteoblasts, we demonstrate that SrRan induces NFATc1 nuclear… CONTINUE READING

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Strontium Ranelate Activates NFATc Signaling in Osteoblasts 25258 JOURNAL OF BIOLOGICAL CHEMISTRY

A. J. Mikels, R. Nusse
PLoS Biol • 2006
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