Essential role of neural Wiskott-Aldrich syndrome protein in neurite extension in PC12 cells and rat hippocampal primary culture cells.

@article{Banzai2000EssentialRO,
  title={Essential role of neural Wiskott-Aldrich syndrome protein in neurite extension in PC12 cells and rat hippocampal primary culture cells.},
  author={Yoshifumi Banzai and Hiroaki Miki and Hideki Yamaguchi and Tadaomi Takenawa},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 16},
  pages={11987-92}
}
Neural Wiskott-Aldrich syndrome protein (N-WASP) is an actin-regulating protein that induces filopodium formation downstream of Cdc42. It has been shown that filopodia actively extend from the growth cone, a guidance apparatus located at the tip of neurites, suggesting their role in neurite extension. Here we examined the possible involvement of N-WASP in the neurite extension process. Since verprolin, cofilin homology and acidic region (VCA) of N-WASP is known to be required for the activation… CONTINUE READING
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