Essential role of mouse telomerase in highly proliferative organs

@article{Lee1998EssentialRO,
  title={Essential role of mouse telomerase in highly proliferative organs},
  author={H. Lee and M. Blasco and G. J. Gottlieb and J. Horner and C. Greider and R. DePinho},
  journal={Nature},
  year={1998},
  volume={392},
  pages={569-574}
}
  • H. Lee, M. Blasco, +3 authors R. DePinho
  • Published 1998
  • Medicine, Biology
  • Nature
  • We have investigated the role of the enzyme telomerase in highly proliferative organs in successive generations of mice lacking telomerase RNA. Late-generation animals exhibited defective spermatogenesis, with increased programmed cell death (apoptosis) and decreased proliferation in the testis. The proliferative capacity of haematopoietic cells in the bone marrow and spleen was also compromised. These progressively adverse effects coincided with substantial erosion of telomeres (the termini of… CONTINUE READING

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