Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

@article{Strub2011EssentialRO,
  title={Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma},
  author={Thomas Strub and Sandy Giuliano and Tao Ye and Caroline Bonet and C{\'e}line Keime and Dominique Kobi and Stephanie Gras and Mireille Cormont and Robert Ballotti and Corine Bertolotto and Irwin Davidson},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={2319-2332}
}
Malignant melanoma is an aggressive cancer known for its notorious resistance to most current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the master regulator determining the identity and properties of the melanocyte lineage, and is regarded as a lineage-specific ‘oncogene’ that has a critical role in the pathogenesis of melanoma. MITF promotes melanoma cell proliferation, whereas sustained supression of MITF expression leads to senescence. By combining… CONTINUE READING