Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.

@article{Gitlin2006EssentialRO,
  title={Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.},
  author={Leonid Gitlin and Winfried Barchet and Susan Gilfillan and Marina Cella and Bruce Beutler and Richard A Flavell and Michael S Diamond and Marco Colonna},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 22},
  pages={
          8459-64
        }
}
The innate immune system recognizes viral dsRNA through two distinct pathways; the Toll-like receptor 3 (TLR3) pathway detects dsRNA phagocytosed in endosomes; the helicases retinoic acid-induced protein I (RIG-I) and melanoma differentiation-associated gene-5 (mda-5) detect cytoplasmic dsRNA generated during viral replication. Both RIG-I and mda-5 can bind polyriboinosinic:polyribocytidylic acid (polyI:C), the synthetic analog of viral dsRNA, and mediate type I IFN responses to polyI:C and… CONTINUE READING

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