Essential role of long non-coding RNAs in de novo chromatin modifications: the genomic address code hypothesis

  title={Essential role of long non-coding RNAs in de novo chromatin modifications: the genomic address code hypothesis},
  author={Ken Nishikawa and Akira R. Kinjo},
  journal={Biophysical Reviews},
  pages={73 - 77}
The epigenome, i.e., the whole of chromatin modifications, is transferred from mother to daughter cells during cell differentiation. When de novo chromatin modifications (establishment or erasure of, respectively, new or pre-existing DNA methylations and/or histone modifications) are made in a daughter cell, however, it has a different epigenome than its mother cell. Although de novo chromatin modification is an important event that comprises elementary processes of cell differentiation, its… 
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