Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

@inproceedings{Yang2014EssentialRO,
  title={Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency},
  author={Yul W Yang and Ryan A Flynn and Yong Chen and Kun Qu and Bingbing Wan and Kevin C Wang and Ming Lei and Howard Y Chang},
  booktitle={eLife},
  year={2014}
}
The WDR5 subunit of the MLL complex enforces active chromatin and can bind RNA; the relationship between these two activities is unclear. Here we identify a RNA binding pocket on WDR5, and discover a WDR5 mutant (F266A) that selectively abrogates RNA binding without affecting MLL complex assembly or catalytic activity. Complementation in ESCs shows that WDR5 F266A mutant is unable to accumulate on chromatin, and is defective in gene activation, maintenance of histone H3 lysine 4 trimethylation… CONTINUE READING
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