Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

@article{Aicher2003EssentialRO,
  title={Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells},
  author={Alexandra Aicher and Christopher Heeschen and Christiane Mildner-Rihm and Carmen Urbich and Christian Ihling and Katja Technau-Ihling and Andreas Michael Zeiher and Stefanie Dimmeler},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={1370-1376}
}
Endothelial nitric oxide synthase (eNOS) is essential for neovascularization. Here we show that the impaired neovascularization in mice lacking eNOS is related to a defect in progenitor cell mobilization. Mice deficient in eNOS (Nos3−/−) show reduced vascular endothelial growth factor (VEGF)-induced mobilization of endothelial progenitor cells (EPCs) and increased mortality after myelosuppression. Intravenous infusion of wild-type progenitor cells, but not bone marrow transplantation, rescued… CONTINUE READING
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