Essential role of dynamin in internalization of M2 muscarinic acetylcholine and angiotensin AT1A receptors.

@article{Werbonat2000EssentialRO,
  title={Essential role of dynamin in internalization of M2 muscarinic acetylcholine and angiotensin AT1A receptors.},
  author={Y Werbonat and N Kleutges and Karl Heinz Jakobs and Chris J van Koppen},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 29},
  pages={21969-74}
}
Most G protein-coupled receptors (GPCRs), including the M(1) muscarinic acetylcholine receptor (mAChR), internalize in clathrin-coated vesicles, a process that requires dynamin GTPase. The observation that some GPCRs like the M(2) mAChR and the angiotensin AT(1A) receptor (AT(1A)R) internalize irrespective of expression of dominant-negative K44A dynamin has led to the proposal that internalization of these GPCRs is dynamin-independent. Here, we report that, contrary to what is postulated… CONTINUE READING

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