Essential role of dengue virus envelope protein N glycosylation at asparagine-67 during viral propagation.

@article{Mondotte2007EssentialRO,
  title={Essential role of dengue virus envelope protein N glycosylation at asparagine-67 during viral propagation.},
  author={Juan A. Mondotte and P Lozach and Ali Amara and Andrea V. Gamarnik},
  journal={Journal of virology},
  year={2007},
  volume={81 13},
  pages={7136-48}
}
Dengue virus envelope protein (E) contains two N-linked glycosylation sites, at Asn-67 and Asn-153. The glycosylation site at position 153 is conserved in most flaviviruses, while the site at position 67 is thought to be unique for dengue viruses. N-linked oligosaccharide side chains on flavivirus E proteins have been associated with viral morphogenesis, infectivity, and tropism. Here, we examined the relevance of each N-linked glycan on dengue virus E protein by removing each site in the… CONTINUE READING
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