Essential role of cyclization sequences in flavivirus RNA replication.

  title={Essential role of cyclization sequences in flavivirus RNA replication.},
  author={Alexander A Khromykh and Hedije Meka and Kimberley Guyatt and Edwin G Westaway},
  journal={Journal of virology},
  volume={75 14},
A possible role in RNA replication for interactions between conserved complementary (cyclization) sequences in the 5'- and 3'-terminal regions of Flavivirus RNA was previously suggested but never tested in vivo. Using the M-fold program for RNA secondary-structure predictions, we examined for the first time the base-pairing interactions between the covalently linked 5' genomic region (first ~160 nucleotides) and the 3' untranslated region (last ~115 nucleotides) for a range of mosquito-borne… CONTINUE READING
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