Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma

@article{Kesanakurti2013EssentialRO,
  title={Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma},
  author={Divya Kesanakurti and C. Sree Ramulu Chetty and Dilip Rajasekhar Maddirela and Meena Gujrati and J. Sunil Rao},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={5144-5155}
}
Although radiotherapy improves survival in patients, glioblastoma multiformes (GBMs) tend to relapse with augmented tumor migration and invasion even after ionizing radiation (IR). Aberrant nuclear factor-κB (NF-κB) and signal transducer and activator of transcription factor 3 (Stat3) activation and interaction have been suggested in several human tumors. However, possible NF-κB/Stat3 interaction and the role of Stat3 in maintenance of NF-κB nuclear retention in GBM still remain unknown. Stat3… CONTINUE READING

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